Cynoglossus_semilaevisFamily: zf-C2H2 Number of Genes: 115
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
insm1b
-
znf648
-
zfpm1
-
bcl6b
-
-
gfi1b
patz1
-
-
zfhx3
-
GZF1
bcl6aa
-
zbtb18
zbtb7b
znf341
-
zbtb24
-
-
-
-
-
-
-
si:ch211-212k18.5
-
zbtb44
si:ch211-79k12.2
-
-
-
-
INSM1 (1 of many)
-
ZNF319
-
-
-
-
zeb2b
-
-
-
-
BNC1
-
zbtb37
zfhx4
-
-
-
-
-
-
-
-
-
-
scrt1b
-
sall3a
-
sall1a
sall3b
-
prdm1a
snai1a
-
si:ch211-236k19.4
-
-
snai2
-
-
-
-
-
sp7
si:dkey-89b17.4
-
zbtb41
znf236
-
znf710b
znf646
-
-
hic1
ZBTB21
PRDM15
-
-
-
-
znf319b
kat5b
sall4
-
-
-
zbtb16b
-
-
-
-
e4f1
-
zbtb16a
znf652
-
-
bcl6ab
zbtb47b
-
GFI1
zbtb34
-
rreb1a
-
-
-
-
ZBTB14
-
-
-
-
-
-
-
-
-
-
znf384l
-
-
-
-
-
hic2
prdm5
zbtb20
-
-
-
-
-
-
-
-
sall2
-
wt1a
-
-
-
-
scrt2

Introduction

Pfam

The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [2].

InterPro

No InterPro abstract

Reference

  1. Boehm S, Frishman D, Mewes HW; , Nucleic Acids Res 1997;25:2464-2469.: Variations of the C2H2 zinc finger motif in the yeast genome and classification of yeast zinc finger proteins. PUBMED:9171100 EPMC:9171100 .

  2. Marco E, Garcia-Nieto R, Gago F; , J Mol Biol 2003;328:9-32.: Assessment by molecular dynamics simulations of the structural determinants of DNA-binding specificity for transcription factor Sp1. PUBMED:12683994 EPMC:12683994.