Microtus_ochrogasterFamily: RRM_1 Number of Genes: 213
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
Cpsf7
-
-
-
-
Eif3b
Rbm42
-
-
Snrnp35
Rbm18
U2surp
-
-
-
-
Rbm46
-
-
Pabpc2
-
Rbm3
Rbm44
-
Pabpc5
-
Rbm15b
Igf2bp3
Rbm4b
Celf3
Rbm25
Nifk
Srsf1
Elavl3
Msi1
Rbm14
Celf6
Ptbp2
Syncrip
Rnps1
Tardbp
Nelfe
U2af1
Eif4h
Dnajc17
Sart3
Cpeb2
-
Rbm11
-
-
Celf2
Mthfsd
-
-
Celf5
-
G3bp1
Hnrnpm
Msi2
-
-
Pspc1
-
-
-
-
Pabpc4
Safb2
-
-
Srsf12
Rbms3
-
-
Ptbp1
-
Pabpc4l
-
-
Pabpn1l
Cstf2
Hnrnph3
Rbm41
Uhmk1
Rbm38
-
-
Ppargc1a
-
Rbfox2
Raly
Rbm7
U2af1l4
-
-
Igf2bp1
-
-
Elavl4
Zcrb1
-
-
Trnau1ap
-
Srsf11
Rbm17
Celf4
Scaf4
Sltm
Hnrnph2
-
-
-
-
-
Celf1
Cirbp
-
-
-
Snrnp70
Enox1
-
Rbm12
Hnrnpl
Srsf5
Rbm15
Pabpc1l
-
Srsf4
Rnpc3
Hnrnpr
Rbm34
-
-
Srsf10
-
-
Hnrnpll
Cpsf6
Rbpms
Safb
Poldip3
-
-
Snrpa
-
-
Tial1
Sf3b6
Hnrnpab
Elavl1
Rbm28
Ppargc1b
Hnrnpf
Scaf8
Rdm1
-
-
Taf15
Rbms2
-
-
-
Rbfox3
-
-
-
-
Tut1
-
-
Tnrc6c
Hnrnpdl
Slirp
Spen
-
-
Cpeb3
Dazl
Rbm24
-
-
Dazap1
Elavl2
Rbm45
Rbm39
-
Ralyl
Rbm5
-
-
-
Rbmx
Dnd1
Raver2
-
-
-
Rbm22
-
Gm20521
Srsf6
-
Puf60
-
-
-
Sfpq
Igf2bp2
-
-
-
-
Alkbh8
-
Enox2
Ptbp3
Rbm26
G3bp2
-
-
-
-
Cstf2t
-
Hnrnph1
-
-
-
Rbfox1
Cnot4
-
-
Srsf9
Rbm47
-
-
-
-
-
-
Ncbp2
Hnrnpd
A1cf
-
Rbpms2
-
-
-
-
Rbm10
Rbms1
-
Boll
-
Cpeb4
-

Introduction

Pfam

The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins (P05455) have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins (P05455) are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.

InterPro

Many eukaryotic proteins containing one or more copies of a putative RNA-binding domain of about 90 amino acids are known to bind single-stranded RNAs [PUBMED:3072706, PUBMED:3192525, PUBMED:3313012]. The largest group of single strand RNA-binding proteins is the eukaryotic RNA recognition motif (RRM) family that contains an eight amino acid RNP-1 consensus sequence [PUBMED:2470643, PUBMED:2467746]. RRM proteins have a variety of RNA binding preferences and functions, and include heterogeneous nuclear ribonucleoproteins (hnRNPs), proteins implicated in regulation of alternative splicing (SR, U2AF, Sxl), protein components of small nuclear ribonucleoproteins (U1 and U2 snRNPs), and proteins that regulate RNA stability and translation (PABP, La, Hu) [PUBMED:3192525, PUBMED:3313012, PUBMED:2467746]. The RRM in heterodimeric splicing factor U2 snRNP auxiliary factor (U2AF) appears to have two RRM-like domains with specialised features for protein recognition [PUBMED:15231733]. The motif also appears in a few single stranded DNA binding proteins.

Reference

  1. Birney E., Kumar S., Krainer A.R. , Nucleic Acid Res 1993;21:5803-5816.: Analysis of the RNA-recognition motif and RS and RGG domains: conservation in metazoan pre-mRNA splicing factors. PUBMED:8290338 EPMC:8290338.