Oryctolagus_cuniculusFamily: RRM_1 Number of Genes: 210
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
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RALY
PPRC1
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PABPC4
SYNCRIP
SRSF12
RBM45
-
-
CELF1
SREK1
RBFOX2
-
HNRNPD
-
SNRPB2
-
SRSF4
-
SFPQ
-
RBM23
RBM3
-
-
RBM15
-
-
-
-
TAF15
HNRNPL
PABPC1L
RBM28
G3BP2
SLTM
RBM42
-
CELF3
TIAL1
-
RNPC3
-
-
SRSF7
ZRSR2
NCL
-
-
-
IGF2BP1
-
-
HNRNPH3
-
-
SF3B4
-
-
RBM4
RBMS3
CELF2
IGF2BP2
DNAJC17
-
-
ELAVL2
RBMS2
PSPC1
RAVER2
-
-
-
RBM10
ENOX1
SRSF3
HNRNPR
-
LARK
NCBP2
-
-
NELFE
RBM39
LARP7
-
-
-
PPIE
PPIL4
-
-
-
SCAF4
RBM18
RBPMS
-
-
TRA2B
CPEB4
-
IGF2BP3
RBM34
SRSF5
RBM19
-
-
-
REXO5
GRSF1
-
ZNF638
HNRNPLL
EIF3B
RBM15B
-
RBM12B
-
RBPMS2
SSB
RBM11
MSI2
CPEB3
CSTF2
-
SPEN
-
-
-
PABPC5
-
-
TIA1
RBM22
A1CF
RBM5
-
-
RBMX2
ALKBH8
RBM47
U2SURP
UHMK1
HTATSF1
ENOX2
-
-
-
MYEF2
-
-
CNOT4
EIF4B
CPSF6
-
RBM25
-
PPARGC1B
BOLL
-
-
RBFOX3
-
SAFB
-
PPARGC1A
HNRNPC
SNRNP70
ELAVL1
RBM41
POLDIP3
PABPN1
ELAVL4
SART3
RBM44
HNRNPH1
-
RBMS1
PTBP2
PTBP3
-
-
EIF4H
-
SETD1B
RBM46
RAVER1
-
-
-
-
-
-
-
-
SNRNP35
-
-
FUS
-
-
-
-
-
-
-
SF3B6
-
-
-
-
-
-
-
-
-
-
-
RDM1
RBM14
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
TRA2A
SRSF9
-
-
-
SNRPA
-
-
CPSF7
CELF4
-
-
-
-
-
-
-
-
RBM8A
SCAF8
HNRNPAB
-
-
-
-
HNRNPA2B1
-
-
-
-
-
-
MSI1
-
-
-
-
-
-
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Introduction

Pfam

The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins (P05455) have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins (P05455) are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.

InterPro

Many eukaryotic proteins containing one or more copies of a putative RNA-binding domain of about 90 amino acids are known to bind single-stranded RNAs [PUBMED:3072706, PUBMED:3192525, PUBMED:3313012]. The largest group of single strand RNA-binding proteins is the eukaryotic RNA recognition motif (RRM) family that contains an eight amino acid RNP-1 consensus sequence [PUBMED:2470643, PUBMED:2467746]. RRM proteins have a variety of RNA binding preferences and functions, and include heterogeneous nuclear ribonucleoproteins (hnRNPs), proteins implicated in regulation of alternative splicing (SR, U2AF, Sxl), protein components of small nuclear ribonucleoproteins (U1 and U2 snRNPs), and proteins that regulate RNA stability and translation (PABP, La, Hu) [PUBMED:3192525, PUBMED:3313012, PUBMED:2467746]. The RRM in heterodimeric splicing factor U2 snRNP auxiliary factor (U2AF) appears to have two RRM-like domains with specialised features for protein recognition [PUBMED:15231733]. The motif also appears in a few single stranded DNA binding proteins.

Reference

  1. Birney E., Kumar S., Krainer A.R. , Nucleic Acid Res 1993;21:5803-5816.: Analysis of the RNA-recognition motif and RS and RGG domains: conservation in metazoan pre-mRNA splicing factors. PUBMED:8290338 EPMC:8290338.