Dipodomys_ordiiFamily: RRM_1 Number of Genes: 188
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
Rbm3
U2af1
-
Rbm39
Dnajc17
-
-
Srsf11
Rbm11
-
Igf2bp2
-
-
Pprc1
Pabpc1l
Enox1
Eif3b
Hnrnpl
Rnps1
Snrnp35
Srsf4
Rbm14
Celf3
Raver2
Elavl3
Ptbp1
Cpsf6
U2af2
Ralyl
Eif3g
Srsf5
Eif4b
Tut1
-
Rbm28
-
-
Tnrc6c
Puf60
Celf6
-
-
Ppie
-
-
Syncrip
Rbm22
Rbfox3
Msi2
-
-
-
Hnrnph1
Hnrnpa2b1
Ssb
Msi1
-
Rbm15
-
Trnau1ap
-
Scaf8
Rbm46
Rbm34
Celf2
Poldip3
Snrpa
Rbms1
Celf4
Ppil4
Cstf2
Rbms3
Zfp638
Hnrnpr
Sltm
Tardbp
-
Rbm5
Rbm41
Hnrnpm
Sfpq
Eif4h
-
-
Rbm19
Alkbh8
Tia1
Hnrnpll
Srsf7
-
-
-
-
Elavl1
Rbms2
Nono
Tra2a
Sf3b6
Rbfox1
Dazap1
-
Rbm47
Snrnp70
Elavl2
-
-
Tial1
Boll
Hnrnpab
-
Uhmk1
Cstf2t
-
Ptbp2
-
Hnrnph3
Dazl
-
Pabpc4
Nelfe
-
-
Cnot4
-
Slirp
Hnrnpd
-
Ppargc1b
Elavl4
Rbm42
Srsf9
Raly
-
Enox2
-
Celf1
Pabpc1
Igf2bp3
Fus
Ptbp3
Sart3
Igf2bp1
Srsf2
Dnd1
Taf15
Rbfox2
Rbm10
Srsf1
Grsf1
-
-
Rbm45
-
Pspc1
Rrp7a
Safb2
Safb
Ppargc1a
Sf3b4
-
-
-
-
-
-
-
Cirbp
-
-
Spen
-
-
-
-
-
-
-
-
-
Srsf10
-
-
-
-
-
-
-
-
-
-
G3bp1
-
Hnrnph2
-
-
-
-
-
-
-
-
-
Rnpc3
-
-
Snrpb2
-
-
-
-
-
-
-
-
-
Srsf6
Rbm24
-
-
-
Rbm18
Ncbp2
-
-
G3bp2
Cpeb3
-
Rbm4b
Rbm7
-
-
-
-

Introduction

Pfam

The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins (P05455) have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins (P05455) are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.

InterPro

Many eukaryotic proteins containing one or more copies of a putative RNA-binding domain of about 90 amino acids are known to bind single-stranded RNAs [PUBMED:3072706, PUBMED:3192525, PUBMED:3313012]. The largest group of single strand RNA-binding proteins is the eukaryotic RNA recognition motif (RRM) family that contains an eight amino acid RNP-1 consensus sequence [PUBMED:2470643, PUBMED:2467746]. RRM proteins have a variety of RNA binding preferences and functions, and include heterogeneous nuclear ribonucleoproteins (hnRNPs), proteins implicated in regulation of alternative splicing (SR, U2AF, Sxl), protein components of small nuclear ribonucleoproteins (U1 and U2 snRNPs), and proteins that regulate RNA stability and translation (PABP, La, Hu) [PUBMED:3192525, PUBMED:3313012, PUBMED:2467746]. The RRM in heterodimeric splicing factor U2 snRNP auxiliary factor (U2AF) appears to have two RRM-like domains with specialised features for protein recognition [PUBMED:15231733]. The motif also appears in a few single stranded DNA binding proteins.

Reference

  1. Birney E., Kumar S., Krainer A.R. , Nucleic Acid Res 1993;21:5803-5816.: Analysis of the RNA-recognition motif and RS and RGG domains: conservation in metazoan pre-mRNA splicing factors. PUBMED:8290338 EPMC:8290338.