Gambusia_affinisFamily: zf-C2H2 Number of Genes: 196
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
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si:dkeyp-113d7.1
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si:ch211-166g5.4
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si:dkey-89b17.4
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zbtb18
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sall3a
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znf652
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wt1b
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ZBTB14
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gfi1b
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scrt2
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zbtb20
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BNC1
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zgc:66448
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si:ch211-212k18.5
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hinfp
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bcl6b
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zbtb47b
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znf512
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bcl6ab
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scrt1b
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zbtb34
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zbtb41
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GZF1
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zfhx4
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sall1a
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patz1
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zbtb16a
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prdm12b
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si:ch211-161m3.4
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zeb1b
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hic1
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zbtb16b
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insm1a
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zfpm1
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sall2
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PRDM15
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ZBTB21
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prdm1b
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bnc2
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znf668
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gfi1ab
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zfhx3
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bcl6aa
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hic2
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GFI1 (1 of many)
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zbtb24
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prdm5
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zbtb44
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sall4
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znf341
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snai1a
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zeb2b
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zbtb49
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snai2
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znf319b
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wt1a
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Introduction

Pfam

The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [2].

InterPro

No InterPro abstract

Reference

  1. Boehm S, Frishman D, Mewes HW; , Nucleic Acids Res 1997;25:2464-2469.: Variations of the C2H2 zinc finger motif in the yeast genome and classification of yeast zinc finger proteins. PUBMED:9171100 EPMC:9171100 .

  2. Marco E, Garcia-Nieto R, Gago F; , J Mol Biol 2003;328:9-32.: Assessment by molecular dynamics simulations of the structural determinants of DNA-binding specificity for transcription factor Sp1. PUBMED:12683994 EPMC:12683994.