Homo_sapiensFamily: DEAD Number of Genes: 76
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
RECQL
DHX33
MTREX
YTHDC2
POLQ
DDX20
DDX3Y
DHX29
DDX1
DDX43
RAD54L
DDX18
DDX24
DDX17
DICER1
SMARCA1
DDX49
DDX58
DDX50
DHX40
RECQL5
DDX5
DHX58
DHX15
DDX25
DDX6
DDX55
ASCC3
IFIH1
DDX59
DDX54
DDX39A
DDX27
DDX31
DHX30
DHX9
DDX56
DDX60
DHX38
EIF4A3
SNRNP200
DDX46
DHX37
DDX4
SMARCA5
TDRD9
EIF4A2
DDX19B
RECQL4
EIF4A1
HFM1
DHX57
HELQ
WRN
DDX21
DDX19A
TDRD12
DDX23
DHX36
DDX10
DDX60L
ERCC6L2
DDX28
DDX41
CMSS1
DDX53
DDX51
FANCM
BLM
DDX42
DDX39B
SKIV2L
DHX16
DDX47
DDX3X
DDX52

Introduction

Pfam

Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.

InterPro

Proteins with this domain include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.

Reference

  1. de la Cruz J, Kressler D, Linder P; , Trends Biochem Sci 1999;24:192-198.: Unwinding RNA in Saccharomyces cerevisiae: DEAD-box proteins and related families. PUBMED:10322435 EPMC:10322435 .

  2. Aubourg S, Kreis M, Lecharny A; , Nucleic Acids Res 1999;27:628-636.: The DEAD box RNA helicase family in Arabidopsis thaliana. PUBMED:9862990 EPMC:9862990.