Ictalurus_punctatusFamily: zf-C2H2 Number of Genes: 138
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
snai2
zbtb49
bcl6b
zbtb16
prdm5
znf512
-
-
znf341
bnc2
-
-
-
zgc:66448
sall2
-
-
sall3b
-
-
zbtb47a
-
znf516
-
hic2
sall3
zbtb24
-
-
-
-
scrt1a
hic1
si:ch211-154o6.2
znf236
-
-
e4f1
-
-
-
-
-
si:dkey-14d8.1
zfhx3
-
-
-
-
-
-
-
znf319b
-
hinfp
zbtb18
zbtb44
-
zbtb11
-
-
-
gfi1ab
wt1
bcl6
-
-
-
ZEB1
zbtb47b
-
znf648
-
zbtb41
ZN12
INSM2
-
gfi1b
-
-
-
si:dkey-89b17.4
-
wt1b
-
-
-
-
-
-
bcl6ab
zbtb16b
-
GFI1 (1 of many)
-
-
prdm1b
hic2
si:dkey-7l6.3
-
zfhx4
-
-
znf711
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
snai1b
zeb1a
znf596
-
-
SALL1
BNC1
-
prdm12b
-
zeb2b
patz1
znf646
-
-
-
-
zbtb21
zfpm1
sall4
-
znf131
zbtb2
PRDM12 (1 of many)
-
-
-
si:ch1073-224n8.1
zbtb20
prdm16
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
ZNF135
-
-
-
sall1b
Znf652
-
-
-
-
-
-
-
-
-
-
-
-
-
-
prdm4
insm1b
-
ZBTB14
zbtb34
znf367

Introduction

Pfam

The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [2].

InterPro

No InterPro abstract

Reference

  1. Boehm S, Frishman D, Mewes HW; , Nucleic Acids Res 1997;25:2464-2469.: Variations of the C2H2 zinc finger motif in the yeast genome and classification of yeast zinc finger proteins. PUBMED:9171100 EPMC:9171100 .

  2. Marco E, Garcia-Nieto R, Gago F; , J Mol Biol 2003;328:9-32.: Assessment by molecular dynamics simulations of the structural determinants of DNA-binding specificity for transcription factor Sp1. PUBMED:12683994 EPMC:12683994.