Mus_pahariFamily: RRM_1 Number of Genes: 192
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
-
-
-
Hnrnpl
U2af1l4
Rbm42
Snrnp70
Rbmxl2
-
Fus
Tial1
-
Rbm4b
-
Rbm14
Tut1
Cpsf7
Cstf2t
-
A1cf
Cpeb3
Pprc1
Alkbh8
Eif3g
-
Elavl3
Rbm7
Celf6
Rbpms2
Sltm
Syncrip
U2surp
Rbm15b
Rbm5
Rbms3
Rbfox1
Igf2bp2
Tra2b
Ncbp2
Rbm11
Scaf4
Zrsr1
Ewsr1
Cpeb2
Ppargc1a
Rbm47
Grsf1
G3bp2
-
Hnrnpd
Hnrnpdl
Cpeb4
Hnrnph1
Hnrnpab
G3bp1
Taf15
Srsf1
Msi2
-
Rdm1
Srsf2
Tnrc6c
Rbfox3
-
-
-
Celf4
Dnd1
Pabpc2
Rbm22
Ppargc1b
Celf2
Rbm17
Rbm24
Nol8
Hnrnpa0
Pabpc1
Puf60
Rbfox2
Poldip3
Zcrb1
-
-
Hnrnpm
Nelfe
Dazl
Safb2
Safb
Hnrnpll
Srsf7
U2af2
Elavl1
Rbpms
Rbm33
Rbm28
Cnot4
Igf2bp3
Tra2a
Hnrnpa2b1
Tia1
-
Mthfsd
Pabpn1l
Rbm34
Scaf8
-
-
Rnps1
-
U2af1
Ppil4
-
Sart3
-
-
Msi1
Rbm19
Setd1b
Snrnp35
Eif4h
Eif3b
Rbm18
Rbms1
-
Hnrnpa3
Rbm45
Celf1
Dnajc17
Myef2
-
-
Snrpb2
Raly
Rbm12
Rbm39
Srsf6
Pabpc1l
Rbm38
Pabpc4l
Rbm46
Celf3
Sf3b4
-
-
Rbm15
Rnpc3
Ptbp2
-
-
-
Srsf11
-
-
-
-
-
-
Boll
Ncl
Rbm44
Nifk
Uhmk1
Ptbp3
Elavl2
Raver2
Elavl4
Ppie
Pabpc4
Sfpq
Srsf4
Trnau1ap
-
-
Hnrnpr
Spen
Tardbp
Sf3b6
Srsf5
Rbm25
-
Hnrnpc
Gm20521
-
Pabpn1
Pspc1
Enox1
Rbm26
Hnrnph3
Ptbp1
Cirbp
Dazap1
-
Rbms2
Cpsf6
Rbm3
Rbm10
-
Enox2
Rbmx
-
Nono
Pabpc5
-
-
Cstf2
Hnrnph2
Rbm41

Introduction

Pfam

The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins (P05455) have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins (P05455) are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.

InterPro

Many eukaryotic proteins containing one or more copies of a putative RNA-binding domain of about 90 amino acids are known to bind single-stranded RNAs [PUBMED:3072706, PUBMED:3192525, PUBMED:3313012]. The largest group of single strand RNA-binding proteins is the eukaryotic RNA recognition motif (RRM) family that contains an eight amino acid RNP-1 consensus sequence [PUBMED:2470643, PUBMED:2467746]. RRM proteins have a variety of RNA binding preferences and functions, and include heterogeneous nuclear ribonucleoproteins (hnRNPs), proteins implicated in regulation of alternative splicing (SR, U2AF, Sxl), protein components of small nuclear ribonucleoproteins (U1 and U2 snRNPs), and proteins that regulate RNA stability and translation (PABP, La, Hu) [PUBMED:3192525, PUBMED:3313012, PUBMED:2467746]. The RRM in heterodimeric splicing factor U2 snRNP auxiliary factor (U2AF) appears to have two RRM-like domains with specialised features for protein recognition [PUBMED:15231733]. The motif also appears in a few single stranded DNA binding proteins.

Reference

  1. Birney E., Kumar S., Krainer A.R. , Nucleic Acid Res 1993;21:5803-5816.: Analysis of the RNA-recognition motif and RS and RGG domains: conservation in metazoan pre-mRNA splicing factors. PUBMED:8290338 EPMC:8290338.