Lepisosteus_oculatusFamily: RRM_1 Number of Genes: 173
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
fus
-
-
-
elavl1b
pabpn1
eif4h
mthfsd
sfpq
u2af1
-
zcrb1
-
ncbp2
taf15
ptbp1b
RNPS1
-
pabpc4
nifk
dazap1
rbms3
-
rbm7
trmt2a
hnrnpc
-
rbm4.3
rbm4.1
-
ptbp3
rbm42
rbm38
safb
BOLL
-
trnau1apa
srsf9
-
eif3bb
-
-
hnrnpr
hnrnpm
rbm26
msi2b
pabpn1l
sart3
celf4
-
ncl
-
setd1ba
celf5a
eif4ba
enox1
srsf10b
celf1
srsf1a
rbms2a
rbm24a
a1cf
dazl
-
celf3b
rbm39a
tardbpl
rbfox1
raver2
ncoa5
alkbh8
rbm45
hnrnpa3
cpeb3
uhmk1
raly
eif3g
zrsr2
raver1
pabpc1l
elavl3
u2surp
si:ch1073-335m2.2
-
ssb
rnpc3
u2af2b
esrp2
ewsr1b
ptbp2b
rbm46
rbm19
zgc:110796
-
rbms1a
mcm3ap
zgc:123010
sf3b4
rbm8a
cpeb4a
scaf4a
hnrnph3
elavl4
-
igf2bp2b
srsf11
-
PABPC1
hnrnpabb
cpeb2
puf60b
rbm27
srek1
hnrnpdl
hnrnpd
rbm5
pspc1
-
rbm22
dnd1
srsf2a
tial1
GRSF1
igf2bp3
-
g3bp1
-
-
ppargc1b
rbfox3a
ppargc1a
srsf5b
hnrnph1
srsf3a
ELAVL2
pprc1
-
dnajc17
ralyl
rbm47
tut1
trnau1apb
RBPMS
myef2
tnrc6c1
rbm15b
-
g3bp2
igf2bp1
zgc:163098
sltm
nol8
alyref
-
srsf5a
rbm25b
rbm10
-
hnrnpl
-
-
SNRPA
nono
rbm41
-
rbpms2b
htatsf1
-
si:dkey-205h23.2
rbmx
cstf2
tia1l
enox2
rbm28
-
rbm17
celf2
srsf7b
HNRNPLL
rbm34
snrpb2
cnot4a
cpsf6
-
sf3b6
SCAF8
syncripl
ppil4
-
-
rbm15
snrnp35
rbm12b
rbm12

Introduction

Pfam

The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins (P05455) have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins (P05455) are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.

InterPro

Many eukaryotic proteins containing one or more copies of a putative RNA-binding domain of about 90 amino acids are known to bind single-stranded RNAs [PUBMED:3072706, PUBMED:3192525, PUBMED:3313012]. The largest group of single strand RNA-binding proteins is the eukaryotic RNA recognition motif (RRM) family that contains an eight amino acid RNP-1 consensus sequence [PUBMED:2470643, PUBMED:2467746]. RRM proteins have a variety of RNA binding preferences and functions, and include heterogeneous nuclear ribonucleoproteins (hnRNPs), proteins implicated in regulation of alternative splicing (SR, U2AF, Sxl), protein components of small nuclear ribonucleoproteins (U1 and U2 snRNPs), and proteins that regulate RNA stability and translation (PABP, La, Hu) [PUBMED:3192525, PUBMED:3313012, PUBMED:2467746]. The RRM in heterodimeric splicing factor U2 snRNP auxiliary factor (U2AF) appears to have two RRM-like domains with specialised features for protein recognition [PUBMED:15231733]. The motif also appears in a few single stranded DNA binding proteins.

Reference

  1. Birney E., Kumar S., Krainer A.R. , Nucleic Acid Res 1993;21:5803-5816.: Analysis of the RNA-recognition motif and RS and RGG domains: conservation in metazoan pre-mRNA splicing factors. PUBMED:8290338 EPMC:8290338.