Neolamprologus_brichardiFamily: RRM_1 Number of Genes: 219
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
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rbm46
-
-
trnau1apb
srsf5a
-
ncl
-
srsf5b
zcrb1
dnajc17
-
-
-
a1cf
alyref
trnau1apa
-
rrp7a
poldip3
-
trmt2a
u2af2a
setd1ba
-
snrnp70
-
RBPMS
rbfox1l
celf3b
rbm14b
-
-
u2af1
rbm25a
htatsf1
-
-
srsf9
rbm15 (1 of many)
cpsf6
taf15
hnrnph3
RBM5
snrpa
-
rbm8a
dazap1
setd1a
-
cpeb2
-
tnrc6c1
dazl
ptbp3
-
CPEB4 (1 of many)
-
si:ch1073-335m2.2
rbm27
rbm19
igf2bp3
tra2a
-
-
-
syncrip
srsf7a
-
hnrnpl
-
tardbpl
srsf3b
REXO5
-
dnd1
-
-
rbm15b
-
larp7
-
srsf1b
-
HNRNPLL (1 of many)
-
-
sart3
eif3g
-
eif3bb
fus
-
rbm45
-
rbm15 (1 of many)
SCAF8
-
-
-
ewsr1b
-
-
pabpc4
-
-
-
rbfox3b
-
si:dkey-205h23.2
-
ptbp1a
-
-
-
raver1
-
-
sltm
ELAVL2
-
elavl3
rbm22
-
-
-
-
srek1
-
ppil4
rbm34
HNRNPA1P48
-
rbfox1
-
-
-
tia1l
-
-
hnrnpaba
celf5a
nifk
g3bp2
-
rnpc3
syncripl
enox2
rbm24a
rbm4.3
-
-
ssb
-
-
-
puf60b
zgc:153215
pabpc1b
sf3b4
pspc1
-
alkbh8
g3bp1
-
-
-
-
rbm41
-
-
-
-
msi2a
-
raly
-
-
enox1
-
-
srsf4
-
rbm12b
rbm47
RBMS1 (1 of many)
eif4bb
hnrnph1
ptbp2a
-
rbm24b
hnrnpm
TRA2B
-
igf2bp2b
-
-
-
cpeb4a
pabpc1l
uhmk1
tial1
rbm39b
-
PABPN1L
nono
rbm7
u2surp
-
srsf10b
-
sfpq
-
-
celf3a
-
rbm4.1
-
-
grsf1
hnrnpr
rbms2b
-
zgc:110796
-
MSI1
-
-
rbm5
rbm17
-
rbfox2
celf4
-
sf3b6
cpeb3
brap
-
nelfe
rbm26
tardbp
hnrnpd
rbms2a
cirbpa
-
-
rbpms2b
-
-
-
snrpb2
rbms1a
eif4h
srsf2b
rbm18
cnot4a
-
zgc:123010
-
zgc:163098
elavl1a
cstf2
-
tut1
-
-
-
-
rbmx
rbm25b
-
-
rbm38
-
-
-
-
-
-
-
-
-
ppargc1a
-
RNPS1
-
-
-
myef2
-
pabpn1
HNRNPLL (1 of many)
-

Introduction

Pfam

The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins (P05455) have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins (P05455) are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.

InterPro

Many eukaryotic proteins containing one or more copies of a putative RNA-binding domain of about 90 amino acids are known to bind single-stranded RNAs [PUBMED:3072706, PUBMED:3192525, PUBMED:3313012]. The largest group of single strand RNA-binding proteins is the eukaryotic RNA recognition motif (RRM) family that contains an eight amino acid RNP-1 consensus sequence [PUBMED:2470643, PUBMED:2467746]. RRM proteins have a variety of RNA binding preferences and functions, and include heterogeneous nuclear ribonucleoproteins (hnRNPs), proteins implicated in regulation of alternative splicing (SR, U2AF, Sxl), protein components of small nuclear ribonucleoproteins (U1 and U2 snRNPs), and proteins that regulate RNA stability and translation (PABP, La, Hu) [PUBMED:3192525, PUBMED:3313012, PUBMED:2467746]. The RRM in heterodimeric splicing factor U2 snRNP auxiliary factor (U2AF) appears to have two RRM-like domains with specialised features for protein recognition [PUBMED:15231733]. The motif also appears in a few single stranded DNA binding proteins.

Reference

  1. Birney E., Kumar S., Krainer A.R. , Nucleic Acid Res 1993;21:5803-5816.: Analysis of the RNA-recognition motif and RS and RGG domains: conservation in metazoan pre-mRNA splicing factors. PUBMED:8290338 EPMC:8290338.