Homo_sapiensFamily: RRM_1 Number of Genes: 213
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
RBM5
REXO5
PTBP1
CELF2
EIF4B
U2AF2
SPEN
ELAVL1
PABPC1
DAZAP1
IGF2BP2
ZNF638
SART3
RBM7
RBMS2
SNRPA
RBFOX1
TNRC6C
CNOT4
PPIE
RBM22
FUS
RBM41
PABPC4
HNRNPC
DAZL
HNRNPH3
SETD1A
CIRBP
HNRNPM
POLDIP3
RBFOX2
RBM23
SRSF5
PABPN1
PABPC1L
CELF4
CSTF2
HTATSF1
RBM3
MTHFSD
DNAJC17
MYEF2
HNRNPL
SNRNP70
EIF3B
RBM28
EIF4H
ELAVL2
CPEB3
PPARGC1A
CPSF6
SRSF9
SRSF3
RBM24
CPEB4
NCBP2
NCL
SF3B6
SRSF7
TIA1
SRSF4
SFPQ
SRSF11
PTBP2
PTBP3
RBM18
SLIRP
RBM25
ENOX1
TARDBP
PSPC1
HNRNPA2B1
RBM19
SRSF6
SNRPB2
HNRNPR
RALY
RBM42
HNRNPH2
SAFB2
EIF3G
PPIL4
RBM39
GRSF1
RBM38
RBM17
RBMX2
MSI1
SYNCRIP
HNRNPA1
IGF2BP3
SRSF1
TRA2B
CPEB2
ALKBH8
SLTM
SSB
HNRNPD
G3BP2
ZCRB1
HNRNPA1L2
SETD1B
RBM26
CELF6
SF3B4
HNRNPLL
RBMS3
G3BP1
NONO
RBMX
A1CF
PPRC1
TUT1
CELF1
CPSF7
PABPC3
TIAL1
RBM46
UHMK1
BOLL
HNRNPDL
RBMS1
SREK1
MSI2
SRSF12
NIFK
RBM45
PPARGC1B
SCAF4
RBPMS
IGF2BP1
CELF3
U2AF1
SAFB
CELF5
U2AF1L4
SRSF2
RAVER1
ELAVL4
RAVER2
RBM15
TDRD10
RBM47
U2SURP
TRA2A
ENOX2
RBPMS2
RBFOX3
HNRNPH1
ZRSR2
RBMY1F
HNRNPF
HNRNPA3
RBMXL2
NCBP2L
RBM4B
RBM4
LARP7
PABPC5
RBMXL3
RBM44
CSTF2T
HNRNPA0
HNRNPCL1
HNRNPCL4
PUF60
TRNAU1AP
RBM10
EWSR1
ALYREF
RBM12B
SNRNP35
PABPC1L2B
RALYL
RBM33
RBM11
RNPC3
PABPC1L2A
DAZ3
DAZ1
SRSF10
RBM34
ELAVL3
HNRNPAB
NOL8
NELFE
PABPN1L
DAZ4
RNPS1
DAZ2
SCAF8
RBMXL1
HNRNPA1P48
RBMY1J
RBMY1A1
RBM14
RBMY1E
RBMY1B
RBMY1D
RBM12
RBM14-RBM4
PABPC4L
DND1
BCL2L2-PABPN1
RBM15B
SRSF8
RBM8A
TAF15
HNRNPCL2
U2AF1L5
HNRNPCL3
RDM1

Introduction

Pfam

The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins (P05455) have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins (P05455) are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.

InterPro

Many eukaryotic proteins containing one or more copies of a putative RNA-binding domain of about 90 amino acids are known to bind single-stranded RNAs [PUBMED:3072706, PUBMED:3192525, PUBMED:3313012]. The largest group of single strand RNA-binding proteins is the eukaryotic RNA recognition motif (RRM) family that contains an eight amino acid RNP-1 consensus sequence [PUBMED:2470643, PUBMED:2467746]. RRM proteins have a variety of RNA binding preferences and functions, and include heterogeneous nuclear ribonucleoproteins (hnRNPs), proteins implicated in regulation of alternative splicing (SR, U2AF, Sxl), protein components of small nuclear ribonucleoproteins (U1 and U2 snRNPs), and proteins that regulate RNA stability and translation (PABP, La, Hu) [PUBMED:3192525, PUBMED:3313012, PUBMED:2467746]. The RRM in heterodimeric splicing factor U2 snRNP auxiliary factor (U2AF) appears to have two RRM-like domains with specialised features for protein recognition [PUBMED:15231733]. The motif also appears in a few single stranded DNA binding proteins.

Reference

  1. Birney E., Kumar S., Krainer A.R. , Nucleic Acid Res 1993;21:5803-5816.: Analysis of the RNA-recognition motif and RS and RGG domains: conservation in metazoan pre-mRNA splicing factors. PUBMED:8290338 EPMC:8290338.