Cyprinodon_variegatusFamily: RRM_1 Number of Genes: 217
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
rbm19
SCAF8
zcrb1
ppil4
u2af2a
-
rbms2a
SRSF6 (1 of many)
-
SRSF6 (1 of many)
-
zgc:103564
-
RBMS1 (1 of many)
safb
-
-
srek1
-
rbm17
-
rnpc3
raver2
-
enox2 (1 of many)
-
-
-
-
-
-
u2surp
nelfe
pabpn1
pprc1
rbm25b
raly (1 of many)
-
srsf3b
-
snrnp70
-
nono
-
-
snrpa
esrp2
-
enox2 (1 of many)
-
srsf4
-
rrp7a
poldip3
-
grsf1
rbfox2
-
TRA2B
igf2bp2b
cirbpa
rbpms2b
cpeb1b
sf3b6
matr3l1.1
uhmk1
zgc:165603
tut1
-
-
pabpc1b
sf3b4
rbm5
tial1
cstf2
cpeb3
brap
-
-
-
-
tardbp
g3bp1
-
srsf7b
rbfox3b
-
alkbh8
CPSF7
-
-
-
rbfox1l
-
-
-
-
-
taf15
rbm4.3 (1 of many)
rbm4.3 (1 of many)
trmt2a
rbmx
igf2bp3
si:ch1073-335m2.2
-
MSI1
scaf4b
celf3b
-
-
puf60b
cnot4a
rbm10
dazl
-
-
-
-
HNRNPH3
rbm28
a1cf
-
rbm22
myef2
-
RNPS1
g3bp2
rbm12b
-
-
-
-
setd1a
rbm24b
zgc:163098
rbm18
slirp
-
syncrip
ncl
hnrnpa1a
snrpb2
dnajc17
ncbp2
rbms2b
rbm15
cpeb2
zgc:123010
eif3g
tia1l
-
rbm14b
ewsr1b
ELAVL2
raver1
RBPMS
elavl3
htatsf1
hnrnph1
-
-
ptbp1a
rbm27
rbms1a
cpsf6
-
alyref
-
-
rbm26
tia1
PABPN1L
rbm42
eif3bb
-
rbm38
rbm39b
rbm45
-
-
-
ppargc1a
-
-
tardbpl
larp7
-
srsf5a
msi2a
elavl1a
srsf5b
zgc:110796
-
-
-
ptbp2b
celf4
-
trnau1apb
igf2bp1
-
celf3a
trnau1apa
-
hnrnpr
nifk
dazap1
-
si:dkey-205h23.2
rbm34
-
rbm15b
hnrnpa3
elavl4
ppie
pabpc4
srsf10b
rbm4.1
-
sfpq
si:dkey-93h22.8
hnrnpaba
hnrnpd
syncripl
srsf7a
rbm47
hnrnpl
rbm24a
rbm8a
hnrnpm
rbm46
-
-
srsf9
-
-
ssb
eif4bb
eif4h
HNRNPLL
pabpc1a
srsf2a
setd1ba
-
-
-
rbms3
mcm3ap
-
sart3
-
rbm7

Introduction

Pfam

The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins (P05455) have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins (P05455) are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.

InterPro

Many eukaryotic proteins containing one or more copies of a putative RNA-binding domain of about 90 amino acids are known to bind single-stranded RNAs [PUBMED:3072706, PUBMED:3192525, PUBMED:3313012]. The largest group of single strand RNA-binding proteins is the eukaryotic RNA recognition motif (RRM) family that contains an eight amino acid RNP-1 consensus sequence [PUBMED:2470643, PUBMED:2467746]. RRM proteins have a variety of RNA binding preferences and functions, and include heterogeneous nuclear ribonucleoproteins (hnRNPs), proteins implicated in regulation of alternative splicing (SR, U2AF, Sxl), protein components of small nuclear ribonucleoproteins (U1 and U2 snRNPs), and proteins that regulate RNA stability and translation (PABP, La, Hu) [PUBMED:3192525, PUBMED:3313012, PUBMED:2467746]. The RRM in heterodimeric splicing factor U2 snRNP auxiliary factor (U2AF) appears to have two RRM-like domains with specialised features for protein recognition [PUBMED:15231733]. The motif also appears in a few single stranded DNA binding proteins.

Reference

  1. Birney E., Kumar S., Krainer A.R. , Nucleic Acid Res 1993;21:5803-5816.: Analysis of the RNA-recognition motif and RS and RGG domains: conservation in metazoan pre-mRNA splicing factors. PUBMED:8290338 EPMC:8290338.