Scleropages_formosusFamily: RRM_1 Number of Genes: 254
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
rbm46
-
rbm34
CPEB4 (1 of many)
rbpms
ssb
srsf2a
rbfox1l
SNRPB2 (1 of many)
rbm24b
rbm18
rbm28
ELAVL2
raver2 (1 of many)
-
pspc1
rbm12b
-
-
ppargc1a (1 of many)
CPSF6 (1 of many)
hnrnpa3
-
-
hnrnpr
g3bp1
uhmk1
cnot4a
ewsr1
nol8
ncoa5
SRSF9
igf2bp1
-
HNRNPA0
-
-
ppargc1b
-
RBM26 (1 of many)
alkbh8
rbm39
alyref (1 of many)
-
snrnp35
-
-
alyref (1 of many)
-
-
-
-
sart3
taf15
enox2
celf5a
rbm38
snrnp70
-
RBFOX3 (1 of many)
-
-
srsf1a
SETD1B (1 of many)
eif4h
zgc:163098
cpeb3
-
-
srek1
rbm19
zcrb1
-
igf2bp1
rbm26
cirbpb
MSI1
tut1
eif3ba
enox1 (1 of many)
hnrnpdl
hnrnpd
snrpa
scaf4a
cstf2
eif3bb
-
-
pabpc1a
-
hnrnpl
setd1a
rbm25
si:ch1073-335m2.2 (1 of many)
-
-
-
SRSF7
ptbp2b
HNRNPLL
-
ppie
REXO5
-
tra2b
igf2bp2b
eif4h
safb
-
-
rbmx
-
srsf5
rbm7
tardbp
rbms3
ncl
tia1
hnrnpm
sf3b4
PTBP2
nono
rbm8a (1 of many)
-
-
sfpq
-
zrsr2
-
zgc:153215
SCAF8
rbm17
cirbpa
-
-
rbm41
si:ch1073-335m2.2 (1 of many)
cpsf7
celf5b
-
u2surp
snrpb2
rbpms2b
-
-
-
rbm10
celf4
SYNCRIP (1 of many)
rbm24a
-
slirp
tial1
dnd1
-
a1cf
htatsf1
-
nifk
msi2b
-
rbm45
raly
-
-
rbm47
pabpn1 (1 of many)
poldip3
rrp7a
-
myef2 (1 of many)
raver2 (1 of many)
-
rnpc3
rbm11
-
-
-
-
-
zgc:56304
tra2a
tardbpl
-
igf2bp3
trnau1apb
dazl
sf3b6
rbms1a (1 of many)
grsf1
pabpn1 (1 of many)
srsf11
rbm22
-
ncbp2
hnrnph3
SRSF6
-
setd1ba
rbm4.3
hnrnpaba
rbms2a
CPSF6 (1 of many)
pabpn1l
elavl4
-
-
-
-
EIF4B (1 of many)
-
hnrnpa1
srsf3a
dnajc17
-
mcm3ap
nelfe
-
CNOT4
srsf9
pabpc1l
trmt2a
-
-
-
myef2 (1 of many)
-
cpeb4
rbm27
elavl2
-
-
ppargc1a (1 of many)
zgc:77262
-
EIF4B (1 of many)
rbm5
u2af2b
pprc1
rbm42
-
larp7
celf1
puf60a
puf60b
-
-
-
-
-
-
-
srsf4
-
dazap1
-
srsf10b
ppil4
zgc:123010
-
ptbp1
ELAVL1
srsf7b
-
sf1
rbpms2
syncrip
celf3a
rbm22 (1 of many)
hnrnpabb
RNPS1
-
hnrnph1l
u2af1
-
enox1 (1 of many)
rbms1
rbfox3a
boll
pabpc4
elavl3
raver1
-
rbfox1
-
eif3g
rbm14b
-
-
RBM47 (1 of many)
rbm8a (1 of many)

Introduction

Pfam

The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins (P05455) have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins (P05455) are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.

InterPro

Many eukaryotic proteins containing one or more copies of a putative RNA-binding domain of about 90 amino acids are known to bind single-stranded RNAs [PUBMED:3072706, PUBMED:3192525, PUBMED:3313012]. The largest group of single strand RNA-binding proteins is the eukaryotic RNA recognition motif (RRM) family that contains an eight amino acid RNP-1 consensus sequence [PUBMED:2470643, PUBMED:2467746]. RRM proteins have a variety of RNA binding preferences and functions, and include heterogeneous nuclear ribonucleoproteins (hnRNPs), proteins implicated in regulation of alternative splicing (SR, U2AF, Sxl), protein components of small nuclear ribonucleoproteins (U1 and U2 snRNPs), and proteins that regulate RNA stability and translation (PABP, La, Hu) [PUBMED:3192525, PUBMED:3313012, PUBMED:2467746]. The RRM in heterodimeric splicing factor U2 snRNP auxiliary factor (U2AF) appears to have two RRM-like domains with specialised features for protein recognition [PUBMED:15231733]. The motif also appears in a few single stranded DNA binding proteins.

Reference

  1. Birney E., Kumar S., Krainer A.R. , Nucleic Acid Res 1993;21:5803-5816.: Analysis of the RNA-recognition motif and RS and RGG domains: conservation in metazoan pre-mRNA splicing factors. PUBMED:8290338 EPMC:8290338.